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San Francisco 49ers vs. Los Angeles Rams 9/17/23 NFL Week 2 Analysis, Best Picks, and Odds

San Francisco 49ers (1-0) vs. Los Angeles Rams (1-0)

Week 2 of the NFL season brings us an NFC West showdown between the San Francisco 49ers (1-0) and the Los Angeles Rams (1-0). Both teams are looking to continue their winning streaks and cement their status as contenders in the conference. This game is pivotal for those looking to make NFL picks today, as it could very well set the tone for the rest of the season for these two powerhouses.

San Francisco boasts a potent offense led by Christian McCaffrey at the running back position. In Week 1, McCaffrey exploded for 152 rushing yards with a staggering 6.9 yards per rush attempt. His capability to churn out big plays was evident with his 65-yard long run, and he also found the end zone once. Equally impressive was wide receiver Brandon Aiyuk. He was targeted 8 times, catching each of those passes for a total of 129 yards and two touchdowns. Aiyuk’s 16.1 yards per reception showcases his big-play ability, making him a formidable weapon in the 49ers’ offensive arsenal.

Kyren Williams led the Rams’ ground game in Week 1 with 52 rushing yards on 15 attempts. While not quite as explosive as his counterpart McCaffrey, Williams showcased his nose for the end zone with two rushing touchdowns. In the receiving department, Puka Nacua was Stafford’s go-to man, grabbing 10 receptions for 119 yards. His performance provided a reliable option for the Rams, and he will need to maintain that consistency against a tough 49ers defense.


San Francisco 49ers vs. Los Angeles Rams Game Info

When: Sunday, September 17, 2023 at 4:05 PM ET
Where: SoFi Stadium
Stream NFL Game Pass


Brock Purdy QB vs. Matthew Stafford QB

Brock Purdy of the San Francisco 49ers seems to be a rising star with impressive stats just one game into the season. Last week, he completed 19 of his 29 passes for 220 yards, achieving a solid 65.5% completion rate. He threw two touchdowns and no interceptions, showing poise and decision-making skills that defy his limited experience in the league. Purdy’s performance was good enough to earn him a passer rating of 111.3, and his chemistry with key receivers like Brandon Aiyuk adds another layer of potency to the 49ers’ already robust offense.

On the opposite end, we have the seasoned veteran Matthew Stafford for the Los Angeles Rams. Stafford showcased his ability to move the ball down the field effectively, accumulating 334 passing yards from 24 completions in 38 attempts. While he didn’t manage to throw a touchdown, his 63.2% completion rate and zero interceptions suggest that he’s still a quarterback who can control the game. His passer rating of 91.3 is not to be taken lightly either. Stafford’s extensive experience, coupled with his new arsenal of weapons like Puka Nacua, could make this a closer game than the odds suggest.


NFL Odds/Point Spread: San Francisco 49ers -350, Total Odds: 44.5

San Francisco is favored by 8 points, which may seem like a steep spread. However, given their recent performances and stronger offensive weapons, the 49ers look to be a solid pick against the spread. The total O/U stands at 44.5, and given the offensive capabilities of both teams, taking the over seems to be a viable option.


San Francisco 49ers Betting Trends

San Francisco is 10-2 ATS in their last 12 games and has an impressive 13-1 SU in their last 14 games. Even more compelling is their 7-0 ATS record in their last 7 games against the Rams. These trends suggest that San Francisco not only wins but covers the spread quite frequently, particularly against the Rams.


Los Angeles Rams Betting Trends 

Los Angeles Rams are 5-2 ATS in their last 7 games, but their performance against the 49ers specifically is less encouraging. They’re 0-5 ATS in their last 5 home games against San Francisco. The Rams have also been struggling to win games outright, with a 3-9 SU record in their last 12 games.


San Francisco 49ers vs. Los Angeles Rams 9/17/23 Betting Picks

Based on the comprehensive data and trends, the San Francisco 49ers seem to be the safer bet for those looking to wager on one of the best betting websites. Their recent performances and favorable matchups in key positions make them a compelling pick. NFL Week 2 presents a fascinating clash between two NFC West rivals. For those looking to best picks, the 49ers appear to be in a stronger position to not only win but also cover the spread.


Free Pick and Prediction: San Francisco 49ers will win 31-21

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