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San Francisco 49ers vs. Jacksonville Jaguars 11/12/23 NFL Week 10 Odds, Picks, and Predictions

San Francisco 49ers (5-3) vs. Jacksonville Jaguars (6-2)

As the NFL progresses into Week 10, a riveting clash awaits between the San Francisco 49ers and the Jacksonville Jaguars. The 49ers, standing at 5-3, are poised to take on the Jaguars, who have carved out a robust 6-2 record, on Sunday. This confrontation, crucial for the postseason landscape, will unfurl at EverBank Stadium. For enthusiasts and analysts making NFL picks today, the upcoming game not only tests each team’s midseason form but also offers a glimpse into potential playoff dynamics.

The 49ers’ offensive machinery has displayed significant prowess in terms of ground and aerial threats. The rushing department, spearheaded by Christian McCaffrey, boasts 137 attempts for 652 yards, with an impressive 4.8-yard average carry, underlining a formidable run game that can dominate the clock and control the game’s tempo. In the receiving corps, Brandon Aiyuk has emerged as a standout, hauling in 35 receptions for 620 yards. His 17.7 yards per catch reflect a game-breaking ability that can exploit any defensive lapses.

Conversely, the Jacksonville Jaguars present a commendable rushing and receiving unit. Travis Etienne Jr.’s contribution to the Jaguars’ rushing game has been substantial, with 151 carries for 583 yards, though his average of 3.9 yards per rush is less than McCaffrey’s, suggesting a potential avenue for the 49ers’ defense to exploit. On the receiving end, Christian Kirk’s 43 catches for 520 yards have been crucial, providing quarterback Trevor Lawrence with a reliable target and maintaining chain movement for the Jaguars’ offense.


San Francisco 49ers vs. Jacksonville Jaguars Game Info

When: Sunday, November 12, 2023 at 1:00 PM ET
Where: EverBank Stadium
Stream: NFL Game Pass


Brock Purdy QB vs. Trevor Lawrence QB

Brock Purdy‘s performance for the 49ers has been notably efficient, with a 68.3% completion rate, 2,033 yards, and 12 touchdowns to his credit over eight games. His ability to maintain a 105.4 passer rating despite 14 sacks indicates resilience and a capacity to deliver under pressure. The challenge ahead is sustaining this level against the Jaguars’ defensive schemes.

For the Jaguars, Trevor Lawrence‘s 68.3% completion rate mirrors Purdy’s accuracy, but with slightly less yardage at 1,935 and an equal number of games played. Lawrence’s challenge against the 49ers will be to elevate his 93.6 passer rating and manage the pocket effectively to mitigate San Francisco’s aggressive pass rush, which has been a notable part of their defensive identity.


NFL Odds/Point Spread: San Francisco 49ers -130, Total Odds: 44.5

The odds present the 49ers as slight favorites, with a -1.5 point spread and a moneyline of -130. This suggests that oddsmakers see them as more likely to emerge victorious, albeit by a slim margin. The total for the game is set at 44.5, with the over slightly favored at -105, indicating expectations of a moderately high-scoring affair.


San Francisco 49ers Betting Trends

The 49ers have been reliable against the spread (ATS), going 13-6 in their last 19 games, a trend that bettors have been keen to follow. Their 16-4 straight-up (SU) record in recent outings underscores their winning capabilities. However, their ATS record on the road and against AFC opponents shows some vulnerability, which should be considered when examining their odds.


Jacksonville Jaguars Betting Trends

The Jaguars’ recent 5-0 ATS and SU records are noteworthy, demonstrating a trend of outperforming expectations. They have shown particular strength at home with a 7-2 SU record in their last 9 games, though their historical performance against NFC opponents raises some concerns, with a 3-17 SU record indicating potential difficulties against the 49ers.


San Francisco 49ers vs. Jacksonville Jaguars 11/12/23 Betting Picks

The analysis of both teams’ performances and betting trends suggests a closely matched encounter, but with the 49ers’ slight edge in offensive versatility and quarterback reliability, they might just tip the scales. However, the Jaguars’ current form cannot be underestimated, especially with their ATS streak.

In terms of top live betting opportunities, the game presents potential for in-play wagers on rushing yards and receptions, given the strengths of McCaffrey and Aiyuk for the 49ers, and Etienne Jr. and Kirk for the Jaguars. The over/under might lean towards the over, considering the offensive firepower of both teams, though it’s worth noting that both defenses have been stout against the run and pass, respectively.


Free Pick and Prediction: San Francisco 49ers 27, Jacksonville Jaguars 24

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