The Originator for over 25 years in Pay Per Head

New York Giants vs. San Francisco 49ers 9/21/23 NFL Week 3 Odds, Picks, and Predictions

New York Giants (1-1) vs. San Francisco 49ers (2-0)

As we enter into Week Three of NFL action, a matchup between the New York Giants and San Francisco 49ers awaits on September 21st at 8:15 PM ET at Levi’s Stadium – broadcast live by AMZN – promises to excite both fans of both teams as well as NFL betting picks enthusiasts alike.

For the Giants in this matchup, key players include running back Saquon Barkley and tight end Darren Waller. Barkley has shown promise rushing statistics but has yet to reach the end zone, while Waller has provided consistent receiving plays but could make more of an impactful difference than his current impactful play suggests.

San Francisco is leaning heavily on quarterback Brock Purdy and running back Christian McCaffrey for their success this season. Purdy has shown tremendous effectiveness with an impressive passer rating of 111.3 while McCaffrey has amassed 152 rushing yards in just one game!


New York Giants vs. San Francisco 49ers Game Info

When:Wednesday, September 21, 2023 at 8:15 PM ET
Where:Levi’s Stadium
Stream:NFL Game Pass


Daniel Jones QB vs. Brock Purdy QB

Daniel Jones has had an inauspicious start to his season. His passer rating currently sits at an uninspiring 32.4, as he’s only managed two interceptions and zero touchdown passes thus far. Yet numbers only tell part of the tale; Jones’ lower-than-average completion percentage (53.6%) and seven total sacks indicate that he’s been put under immense defensive pressure; this puts him at a significant disadvantage against San Francisco’s formidable defense because his decision-making and scanning abilities under pressure haven’t been as developed; therefore to give San Francisco an edge against their formidable defense, Jones will need to find ways of finding ways of getting to their key playmakers like Saquon Barkley and Darren Waller while avoiding turnovers while keeping defenses at bay.

Brock Purdy of the San Francisco 49ers has started off his season on an impressive note, posting an impressive passer rating of 111.3 while throwing for 220 yards, completing 65.5% of his passes, scoring two touchdowns without an interception – all without making one single mistake on offense! Purdy stands out against Jones because of his ability to stay cool under pressure while making quick smart decisions; Christian McCaffrey and Brandon Aiyuk will help maximize this advantage against Jones.


NFL Odds/Point Spread: San Francisco 49ers -450, Total Odds: 45.5

Current betting odds favor the 49ers with a moneyline of -450 and point spread set at 10.5, making the Giants underdogs. Based on performance and matchup, these odds appear appropriate.


New York Giants Betting Trends

The Giants have experienced mixed results when it comes to betting trends. Overall, they have posted 12-6 against the spread (ATS) in their last 18 games but struggle against San Francisco (1-4 ATS in 5 meetings). Notably, however, they fare better away from home with an 8-3 ATS record in their last 11 road games, specifically against San Francisco on their travels (5-2 against them overall!). Yet overall they struggle against NFC West teams.


San Francisco 49ers Betting Trends

San Francisco has been an impressive team over the last 13 games, posting a 10-3 against-the-spread (ATS) record in 13 of them and going 14-1 straight-up (SU) since 15 September 2017. At home they’ve been even stronger, going unbeaten against ATS for seven straight home games against any team aside from New York Giants (2-5 against-ATS in total). Unfortunately for San Francisco this may prove problematic given that other factors make SF’s narrative much stronger than their performance against New York Giants when playing at home against them which could alter their otherwise positive narrative significantly.


New York Giants vs. San Francisco 49ers 9/21/23 Betting Picks

Based on current stats and trends, it’s hard to bet against the 49ers given their strength both defensively and offensively; their record at both ATS and SU is nearly flawless. On the other hand, Giants tend to perform better away from Levi’s Stadium making this matchup more unpredictable than expected.

If you want a safe pick, the 49ers appear to be an optimal selection. With an over/under set at 45.5 and given New York’s offensive struggles compared with San Francisco’s strong defense, betting under may be your best bet – make sure you consider this matchup carefully before exploring your options on live betting websites.


Free Pick and Prediction: San Francisco 49ers 28, New York Giants 14

Start your online gaming site with IDSCA

Try us for a week for free, and explore all the tools and services you need to start, run, and grow your online sports betting business.


Complete the signup form


Select template and
configure your site
thumb-sportsbook copy


Promote your site and
start collecting money
Freedom to bet from anywhere

We are here with you every step of the way

Every hour of every day, we will have experts standing by to help you with every step of your journey. From setup, to how to maximize your player's experience -- our team is here to help.


Exciting bets
Live Chat